ROLE OF VARIOUS MODALITIES IN STIMULATING OSTEOGENESIS
- Growth factors and related molecules
- BMP 2and 7
- Transforming growth factor TGF beta
- Fibroblast growth factor FGF 1and2
- PDGF
- PGE2
- Systemic enhancement
- Parathyroid hormone
- role of teriparatide in osteoporotic #
- growth hormone, insulin like growth factors
- Physical enhancement
- mechanical stimulation – role of micromotion
- intermittent compressive / shear forces – enchondral ossification
- tensile stress – intramembranous ossification
- constant compressive stresses (hydrostatic stress ) - inhibit enchondral ossification - cartilage
- high shear stress – fibrous tissue formation
- distraction osteogenesis – in non union
- electrical stimulation
- ultrasound stimulation
- Bone grafts
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